Squamous Cell Cancer-Head/Neck

Squamous cell carcinomas of the head and neck (SCCHN) are a group of cancers that develop from a thin, moist layer of squamous cellscalled a mucosal surfacethat line the inner structures of the head and neck, such as the mouth, nose, and throat.
Cancer cells use a variety of ways to avoid the bodys natural defensethe immune systemto continue to grow, invade, and spread.
In SCCHN, molecular interactions between PD-1 on our immune systems T-cells and PD-L1 on cancer cells drive whether or not the bodys immune system will attack a cancer cell.
This program will look at the cellular underpinnings of SCCHN, as well as agentsknown as checkpoint inhibitorsthat target PD-1 or PD-L1 for improved management of this condition.,

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